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KMID : 0829220020260040281
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Korean Journal of Oral and Maxillofacial Pathology
2002 Volume.26 No. 4 p.281 ~ p.290
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Gene Screening in Cyclosporin A Induced Gingival Overgrowth Using Differential Display PCR
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김옥준/Kim OJ
최홍란/정지연/고정태/박종태/정병철/문정선/김원재/김현진/김선헌/Choi HR/Jung JY/Koh JT/Park JT/Jeong BC/Moon JS/Kim WJ/Kim HJ/Kim SH
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Abstract
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Cyclosporin A(CsA) is a polypeptide composed of 11 amino acied used as a widely spread immunosuppressive drug to prevent transplant rejection and also in the treatment of various pathological condition. The CsA treatment may cause various side effects including gingival overgrowth. However, its molecular events are not well understood.
Twenty male Sprague-Dawley rats weighing about 150g were injected by CsA at a concentration of 10 ㎎/㎏ for 8 weeks. Gingival overgrowth at lower incisors was confirmed by histologic findings. To investigate the CsA role in gingival overgrowth, differential display(DD)-PCR was carried out. One of the under-expressed genes in CsA-treated rats was a VDAC2, which is located in the outer membrane of mitochondria.
Considering the role of VDAC2, as the gate for mitochondria-dependent apoptotic molecules, anti-apoptotic changes are suggested in CsA-induced gingival overgrowth.
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